ntegrative healthcare is an approach that combines conventional Western medicine with complementary and alternative therapies to address the physical, emotional, mental, social, and spiritual aspects of health and wellness. It emphasizes a patient-centered, holistic approach that considers the whole person, rather than just focusing on treating specific symptoms or diseases.
2006 – Epidemiology of Refractory Neuropathic Pain.docx Rod S. Taylor, MSc, PhD Department of Public Health & Epidemiology, University of Birmingham, Birmingham, U.K. Abstract Although neuropathic pain can be acute in nature, in most patients the pain is persistent (or “refractory”). Patients with chronic neuropathic pain are seen most often in clinical practice. It consists…
Practice Essentials Diabetic neuropathy is the most common complication of diabetes mellitus (DM), affecting as many as 50% of patients with type 1 and type 2 DM. Diabetic peripheral neuropathy involves the presence of symptoms or signs of peripheral nerve dysfunction in people with diabetes after other possible causes have been excluded. Essential update: Screening…
Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.
Aging (Albany NY). 2024 Apr 4;16. doi: 10.18632/aging.205717. Online ahead of print.
ABSTRACT
Despite their biological importance, the role of stem cells in human aging remains to be elucidated. In this work, we applied a machine learning methodology to GTEx transcriptome data and assigned stemness scores to 17,382 healthy samples from 30 human tissues aged between 20 and 79 years. We found that ~60% of the studied tissues exhibit a significant negative correlation between the subject’s age and stemness score. The only significant exception was the uterus, where we observed an increased stemness with age. Moreover, we observed that stemness is positively correlated with cell proliferation and negatively correlated with cellular senescence. Finally, we also observed a trend that hematopoietic stem cells derived from older individuals might have higher stemness scores. In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during hu..
