Stem Cell Exhaustion and Mitochondrial Dysfunction: Implications for Cellular Senescence and Regenerative Medicine
Abstract Stem cell exhaustion is a critical factor contributing to aging and associated pathologies, characterized by a decline in the regenerative capacity of tissues. This review explores the intricate relationship between stem cell exhaustion and mitochondrial dysfunction, elucidating how impaired mitochondrial dynamics and bioenergetics contribute to the decline in stem cell function. We discuss the…