Dr Graham Simpson’s I.N.T.E.G.R.A.L protocol and the additive benefits of EcST
There are 8 root causes responsible for most chronic disease. The I.N.T.E.G.R.A.L model was invented…
There are 8 root causes responsible for most chronic disease. The I.N.T.E.G.R.A.L model was invented…
Title: Glucose-Restriction Induced Longevity: Mechanisms and Implication Abstract Glucose restriction (GR) has emerged as a…
Longevity medicine is a burgeoning field of medicine focused on the science of aging and…
Introduction Mitochondria are important organelles that are constantly moving and involved in producing ATP, maintaining…
The relationship between cyclic adenosine monophosphate (cAMP) signaling and Electric Cell Signaling (ECS) treatments is…
Date:August 29, 2023 Source: University of California – San Diego Summary:Researchers investigated the associations of…
Date:September 26, 2022 Source:European Society of Cardiology Summary:Drinking two to three cups of coffee a…
Columbia University’s Mailman School of Public Health. “Pregnancy accelerates biological aging in a healthy, young adult population.” ScienceDaily. ScienceDaily, 8 April 2024.
Columbia University’s Mailman School of Public Health. (2024, April 8). Pregnancy accelerates biological aging in a healthy, young adult population. ScienceDaily. Retrieved April 14, 2024 from www.sciencedaily.com/releases/2024/04/240408150449.htm
Columbia University’s Mailman School of Public Health. “Pregnancy accelerates biological aging in a healthy, young adult population.” ScienceDaily. www.sciencedaily.com/releases/2024/04/240408150449.htm (accessed April 14, 2024).
Aging (Albany NY). 2024 Apr 4;16. doi: 10.18632/aging.205717. Online ahead of print.
ABSTRACT
Despite their biological importance, the role of stem cells in human aging remains to be elucidated. In this work, we applied a machine learning methodology to GTEx transcriptome data and assigned stemness scores to 17,382 healthy samples from 30 human tissues aged between 20 and 79 years. We found that ~60% of the studied tissues exhibit a significant negative correlation between the subject’s age and stemness score. The only significant exception was the uterus, where we observed an increased stemness with age. Moreover, we observed that stemness is positively correlated with cell proliferation and negatively correlated with cellular senescence. Finally, we also observed a trend that hematopoietic stem cells derived from older individuals might have higher stemness scores. In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during hu..