Electric Cell Signaling and Stem Cell Activity
Electrical fields and electric cell signaling play a crucial role in regulating stem cell activity.…
Electrical fields and electric cell signaling play a crucial role in regulating stem cell activity.…
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Columbia University’s Mailman School of Public Health. “Pregnancy accelerates biological aging in a healthy, young adult population.” ScienceDaily. www.sciencedaily.com/releases/2024/04/240408150449.htm (accessed April 14, 2024).
Abstract Electric cell signaling treatment (ECST) represents a promising therapeutic modality that harnesses electrical signals…
1. Enhanced Tissue Healing: EcST and electrical stimulation promote the healing process by accelerating tissue…
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Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.
Aging (Albany NY). 2024 Apr 4;16. doi: 10.18632/aging.205717. Online ahead of print.
ABSTRACT
Despite their biological importance, the role of stem cells in human aging remains to be elucidated. In this work, we applied a machine learning methodology to GTEx transcriptome data and assigned stemness scores to 17,382 healthy samples from 30 human tissues aged between 20 and 79 years. We found that ~60% of the studied tissues exhibit a significant negative correlation between the subject’s age and stemness score. The only significant exception was the uterus, where we observed an increased stemness with age. Moreover, we observed that stemness is positively correlated with cell proliferation and negatively correlated with cellular senescence. Finally, we also observed a trend that hematopoietic stem cells derived from older individuals might have higher stemness scores. In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during hu..
Aging Dis. 2024 Apr 9. doi: 10.14336/AD.2024.0331. Online ahead of print.
ABSTRACT
The characteristics of human aging manifest in tissue and organ function decline, heightening susceptibility to age-related ailments, thereby presenting novel challenges to fostering and sustaining healthy longevity. In recent years, an abundance of research on human aging has surfaced. Intriguingly, evidence suggests a pervasive correlation among gut microbiota, bodily functions, and chronic diseases. From infancy to later stages of adulthood, healthy individuals witness dynamic shifts in gut microbiota composition. This microbial community is associated with tissue and organ function deterioration (e.g., brain, bones, muscles, immune system, vascular system) and heightened risk of age-related diseases. Thus, we present a narrative review of the aging gut microbiome in both healthy and unhealthy aging contexts. Additionally, we explore the potential for adjustments to physical health based on gut microb..